rat FCGR2B shRNA silencing AAV

Name
AAV-r-FCGR2B-shRNA

Cat No
shAAV-293258

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Fcgr2b.

shAAV-293258

AAV-r-FCGR2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Fcgr2b (Fc fragment of IgG, low affinity IIb, receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD32; FcgammaRIIB2; Fcgr2; FCRII

Description (Vector)

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Gene ID

289211

Gene Name (Vector)

Fc fragment of IgG, low affinity IIb, receptor

Gene Symbol

Fcgr2b

ORF Size (aa)

858

RefSeq ID

NM_175756

RefSeq Synonyms

NM_175756, BC091113,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.