rat TSPAN12 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Tspan12.
shAAV-293196
AAV-r-TSPAN12-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Tspan12 (tetraspanin 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Tm4sf12
Description (Vector)
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
Gene ID
362326
Gene Name (Vector)
tetraspanin 12
Gene Symbol
Tspan12
ORF Size (aa)
918
RefSeq ID
NM_001015026
RefSeq Synonyms
NM_001015026, BC092623,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.