rat ITM2C shRNA silencing AAV

Name
AAV-r-ITM2C-shRNA

Cat No
shAAV-292503

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Itm2c.

shAAV-292503

AAV-r-ITM2C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Itm2c (integral membrane protein 2C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

Gene ID

301575

Gene Name (Vector)

integral membrane protein 2C

Gene Symbol

Itm2c

ORF Size (aa)

810

RefSeq ID

NM_001009674

RefSeq Synonyms

NM_001009674, BC087127,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.