rat SPPL2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Sppl2b.
shAAV-292501
AAV-r-SPPL2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Sppl2b (signal peptide peptidase-like 2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGD1308556
Description (Vector)
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
Gene ID
362828
Gene Name (Vector)
signal peptide peptidase-like 2B
Gene Symbol
Sppl2b
ORF Size (aa)
1734
ORF Size (bp)
1734 bp
RefSeq ID
NM_001014200
RefSeq Synonyms
NM_001014200, BC087132,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.