rat HTRA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Htra1.
shAAV-291609
AAV-r-HTRA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Htra1 (HtrA serine peptidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Prss11
Description (Vector)
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Gene ID
65164
Gene Name (Vector)
HtrA serine peptidase 1
Gene Symbol
Htra1
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
RefSeq ID
NM_031721
RefSeq Synonyms
NM_031721, BC081767,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.