rat CYR61 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Cyr61.
shAAV-291493
AAV-r-CYR61-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Cyr61 (cysteine-rich, angiogenic inducer, 61). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Gene ID
83476
Gene Name (Vector)
cysteine-rich, angiogenic inducer, 61
Gene Symbol
Cyr61
ORF Size (aa)
1140
ORF Size (bp)
1140 bp
RefSeq ID
NM_031327
RefSeq Synonyms
NM_031327, BC081689,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.