rat WDR79 shRNA silencing AAV

Name
AAV-r-WDR79-shRNA

Cat No
shAAV-291353

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Wrap53.

shAAV-291353

AAV-r-WDR79-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Wrap53 (WD repeat containing, antisense to TP53). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Wdr79

Description (Vector)

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Gene ID

287432

Gene Name (Vector)

WD repeat containing, antisense to TP53

Gene Symbol

Wrap53

ORF Size (aa)

1599

ORF Size (bp)

1599 bp

RefSeq ID

NM_001007610

RefSeq Synonyms

NM_001007610, BC083696,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.