rat PTBP2 shRNA silencing AAV

Name
AAV-r-PTBP2-shRNA

Cat No
shAAV-290925

Availability
Immediate

This is an AAV expressing shRNA for silencing of Rat Ptbp2.

shAAV-290925

AAV-r-PTBP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Ptbp2 (polypyrimidine tract binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Ptb2; PTBLP; PTBLP-L; PTBLP-S

Description (Vector)

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.

Gene ID

310820

Gene Name (Vector)

polypyrimidine tract binding protein 2

Gene Symbol

Ptbp2

ORF Size (aa)

1596

ORF Size (bp)

1596 bp

RefSeq ID

NM_001005555

RefSeq Synonyms

NM_001005555, BC082076,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.