rat CASQ2 shRNA silencing AAV

Name
AAV-r-CASQ2-shRNA

Cat No
shAAV-290603

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Casq2.

shAAV-290603

AAV-r-CASQ2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Casq2 (calsequestrin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cardCSQ

Description (Vector)

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions.

Gene ID

29209

Gene Name (Vector)

calsequestrin 2

Gene Symbol

Casq2

ORF Size (aa)

1284

ORF Size (bp)

1284 bp

RefSeq ID

NM_017131

RefSeq Synonyms

NM_017131, BC072547,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.