rat DYNLL1 shRNA silencing AAV

Name 
AAV-r-DYNLL1-shRNA
Cat No 
shAAV-290441
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Rat Dynll1.

shAAV-290441
AAV-r-DYNLL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Dynll1 (dynein light chain LC8-type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
96
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
8kDLC; Dlc8; Dnclc1; Pin
Description (Vector)
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures|Function: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase|Function: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1|Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Gene ID
58945
Gene Name (Vector)
dynein light chain LC8-type 1
Gene Symbol
Dynll1
ORF Size (aa)
270
ORF Size (bp)
270 bp
RefSeq ID
NM_053319
RefSeq Synonyms
NM_053319, BC063183,
Species
rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.