mouse PLCD4 shRNA silencing AAV

Name
AAV-m-PLCD4-shRNA

Cat No
shAAV-280978

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Plcd4.

shAAV-280978

AAV-m-PLCD4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Plcd4 (phospholipase C, delta 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

4921507K24Rik

Description (Vector)

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Gene ID

18802

Gene Name (Vector)

phospholipase C, delta 4

Gene Symbol

Plcd4

ORF Size (aa)

2328

ORF Size (bp)

2328 bp

RefSeq ID

NM_148937

RefSeq Synonyms

NM_148937, NM_001081456, BC066156,

Species

mouse

UniGene ID

Mm.290731

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.