mouse DKK1 shRNA silencing AAV

Name
AAV-m-DKK1-shRNA

Cat No
shAAV-280686

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Dkk1.

shAAV-280686

AAV-m-DKK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dkk1 (dickkopf WNT signaling pathway inhibitor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

mdkk-1

Description (Vector)

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene ID

13380

Gene Name (Vector)

dickkopf WNT signaling pathway inhibitor 1

Gene Symbol

Dkk1

ORF Size (aa)

819

ORF Size (bp)

819 bp

RefSeq ID

NM_010051

RefSeq Synonyms

NM_010051, BC050189,

Species

mouse

UniGene ID

Mm.214717

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.