mouse CRBN shRNA silencing AAV

Cat. No: shAAV-280509

Availability: 4-5 weeks

Name: AAV-m-CRBN-shRNA

This is an AAV expressing shRNA for silencing of Mouse Crbn.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Crbn
Gene Name: cereblon
Gene ID: 58799
Gene Synonyms: 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL
ORF Size: 1296 bp
RefSeq#: NM_021449
Gene Description: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
UniGene ID: Mm.290085