mouse BRMS1 shRNA silencing AAV

Name
AAV-m-BRMS1-shRNA

Cat No
shAAV-278936

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Brms1.

shAAV-278936

AAV-m-BRMS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Brms1 (breast cancer metastasis-suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AV003220; AW554636

Description (Vector)

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene ID

107392

Gene Name (Vector)

breast cancer metastasis-suppressor 1

Gene Symbol

Brms1

ORF Size (aa)

741

RefSeq ID

NM_134155

RefSeq Synonyms

NM_134155, BC016108, BC003485,

Species

mouse

UniGene ID

Mm.478009

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.