mouse ZFAND5 shRNA silencing AAV

Name
AAV-m-ZFAND5-shRNA

Cat No
shAAV-277866

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Zfand5.

shAAV-277866

AAV-m-ZFAND5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Zfand5 (zinc finger, AN1-type domain 5). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2310057A04Rik; 5830475F03Rik; AA415485; Za20d2; Zfp216

Description (Vector)

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Gene ID

22682

Gene Name (Vector)

zinc finger, AN1-type domain 5

Gene Symbol

Zfand5

ORF Size (aa)

642

RefSeq ID

NM_009551

RefSeq Synonyms

NM_009551, BC119126, BC119124, BC107566,

Species

mouse

UniGene ID

Mm.292405

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.