mouse UXT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Uxt.
shAAV-275787
AAV-m-UXT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Uxt (ubiquitously expressed transcript). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0910002B17Rik
Description (Vector)
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
Gene ID
22294
Gene Name (Vector)
ubiquitously expressed transcript
Gene Symbol
Uxt
ORF Size (aa)
360
RefSeq ID
NM_013840
RefSeq Synonyms
NM_013840, BC082294, BC029258,
Species
mouse
UniGene ID
Mm.34779
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.