mouse UMOD shRNA silencing AAV

Name
AAV-m-UMOD-shRNA

Cat No
shAAV-275624

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Umod.

shAAV-275624

AAV-m-UMOD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Umod (uromodulin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

THP; Urehd1; urehr4

Description (Vector)

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serves as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial|Function: Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

Gene ID

22242

Gene Name (Vector)

uromodulin

Gene Symbol

Umod

ORF Size (aa)

1929

ORF Size (bp)

1929 bp

RefSeq ID

NM_009470

RefSeq Synonyms

NM_009470, NM_001278605, BC012973,

Species

mouse

UniGene ID

Mm.10826

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.