mouse ULBP1 shRNA silencing AAV

Name
AAV-m-ULBP1-shRNA

Cat No
shAAV-275615

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Ulbp1.

shAAV-275615

AAV-m-ULBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ulbp1 (UL16 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A430108B07Rik; MULT1

Description (Vector)

Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene ID

77777

Gene Name (Vector)

UL16 binding protein 1

Gene Symbol

Ulbp1

ORF Size (aa)

1005

ORF Size (bp)

1005 bp

RefSeq ID

NM_029975

RefSeq Synonyms

NM_029975, BC132072, BC132070,

Species

mouse

UniGene ID

Mm.442442

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.