mouse UBE2V1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ube2v1.
shAAV-275505
AAV-m-UBE2V1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ube2v1 (ubiquitin-conjugating enzyme E2 variant 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610011J09Rik; AI256840; CROC-1; CROC1; D7Bwg1382e; UEV-1
Description (Vector)
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Gene ID
66589
Gene Name (Vector)
ubiquitin-conjugating enzyme E2 variant 1
Gene Symbol
Ube2v1
ORF Size (aa)
318
RefSeq ID
NM_023230
RefSeq Synonyms
NM_023230, NM_001311146, NM_001311131, BC092253, BC019372, BC003449,
Species
mouse
UniGene ID
Mm.360108
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.