mouse TSC1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tsc1.
shAAV-275119
AAV-m-TSC1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tsc1 (tuberous sclerosis 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Gene ID
64930
Gene Name (Vector)
tuberous sclerosis 1
Gene Symbol
Tsc1
ORF Size (aa)
3447
ORF Size (bp)
3447 bp
RefSeq ID
NM_022887
RefSeq Synonyms
NM_022887, NM_001289576, NM_001289575, BC052399,
Species
mouse
UniGene ID
Mm.224354
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.