mouse TOPBP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Topbp1.
shAAV-274820
AAV-m-TOPBP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Topbp1 (topoisomerase (DNA) II binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; mKIAA0259
Description (Vector)
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
Gene ID
235559
Gene Name (Vector)
topoisomerase (DNA) II binding protein 1
Gene Symbol
Topbp1
ORF Size (aa)
4548
ORF Size (bp)
4548 bp
RefSeq ID
NM_176979
RefSeq Synonyms
NM_176979, BC049797,
Species
mouse
UniGene ID
Mm.259893
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.