mouse TNIP2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tnip2.
shAAV-274746
AAV-m-TNIP2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tnip2 (TNFAIP3 interacting protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810020H16Rik; ABIN-2; AI428870
Description (Vector)
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Gene ID
231130
Gene Name (Vector)
TNFAIP3 interacting protein 2
Gene Symbol
Tnip2
ORF Size (aa)
1356
ORF Size (bp)
1356 bp
RefSeq ID
NM_139064
RefSeq Synonyms
NM_139064, BC052083,
Species
mouse
UniGene ID
Mm.28615
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.