mouse TGS1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tgs1.
shAAV-274130
AAV-m-TGS1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tgs1 (trimethylguanosine synthase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D4Ertd800e; Ncoa6ip; Pimt
Description (Vector)
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Gene ID
116940
Gene Name (Vector)
trimethylguanosine synthase 1
Gene Symbol
Tgs1
ORF Size (aa)
2562
ORF Size (bp)
2562 bp
RefSeq ID
NM_054089
RefSeq Synonyms
NM_054089, BC075728,
Species
mouse
UniGene ID
Mm.171323
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.