mouse TGFBR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tgfbr1.
shAAV-274108
AAV-m-TGFBR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tgfbr1 (transforming growth factor, beta receptor I). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Alk-5; ALK5; AU017191; ESK2; TbetaR-I; TbetaRI; TGFR-1
Description (Vector)
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Gene ID
21812
Gene Name (Vector)
transforming growth factor, beta receptor I
Gene Symbol
Tgfbr1
ORF Size (aa)
1512
ORF Size (bp)
1512 bp
RefSeq ID
NM_009370
RefSeq Synonyms
NM_009370, NM_001312869, NM_001312868, BC063260,
Species
mouse
UniGene ID
Mm.197552
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.