mouse TCHP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tchp.
shAAV-273946
AAV-m-TCHP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tchp (trichoplein, keratin filament binding). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A930031F18Rik; AV279199
Description (Vector)
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Gene ID
77832
Gene Name (Vector)
trichoplein, keratin filament binding
Gene Symbol
Tchp
ORF Size (aa)
1383
ORF Size (bp)
1383 bp
RefSeq ID
NM_029992
RefSeq Synonyms
NM_029992, BC043048,
Species
mouse
UniGene ID
Mm.239698
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.