mouse TCEB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Elob.
shAAV-273904
AAV-m-TCEB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Elob (elongin B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610040H15Rik; Tceb2
Description (Vector)
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)|Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Gene ID
67673
Gene Name (Vector)
elongin B
Gene Symbol
Elob
ORF Size (aa)
357
RefSeq ID
NM_026305
RefSeq Synonyms
NM_026305, BC056983, BC051927,
Species
mouse
UniGene ID
Mm.153758
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.