mouse TBK1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tbk1.
shAAV-273840
AAV-m-TBK1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tbk1 (TANK-binding kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1200008B05Rik; AI462036; AW048562
Description (Vector)
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFN-alpha and IFN-beta. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS or SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates and activates AKT1. Phosphorylates Borna disease virus (BDV) P protein.
Gene ID
56480
Gene Name (Vector)
TANK-binding kinase 1
Gene Symbol
Tbk1
ORF Size (aa)
2190
ORF Size (bp)
2190 bp
RefSeq ID
NM_019786
RefSeq Synonyms
NM_019786, BC129911, BC129910,
Species
mouse
UniGene ID
Mm.34580
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.