mouse TBCD shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tbcd.
shAAV-273836
AAV-m-TBCD-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tbcd (tubulin-specific chaperone d). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310057L06Rik; A030005L14Rik; mKIAA0988
Description (Vector)
Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
Gene ID
108903
Gene Name (Vector)
tubulin-specific chaperone d
Gene Symbol
Tbcd
ORF Size (aa)
3591
ORF Size (bp)
3591 bp
RefSeq ID
NM_029878
RefSeq Synonyms
NM_029878, BC059843,
Species
mouse
UniGene ID
Mm.23686
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.