mouse SYTL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse SYTL2.
shAAV-273575
AAV-m-SYTL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse SYTL2 (synaptotagmin-like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI266830; mKIAA1597; Slp2
Description (Vector)
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Gene ID
83671
Gene Name (Vector)
synaptotagmin-like 2
Gene Symbol
SYTL2
ORF Size (aa)
2853
ORF Size (bp)
2853 bp
RefSeq ID
NM_031394
RefSeq Synonyms
NM_031394, NM_001289586, NM_001289585, NM_001289584, NM_001289583, NM_001040088, NM_001040087, NM_001040086, NM_001040085, BC145398, BC138714,
Species
mouse
UniGene ID
Mm.26751
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.