mouse SYT1 shRNA silencing AAV

Name
AAV-m-SYT1-shRNA

Cat No
shAAV-273547

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Syt1.

shAAV-273547

AAV-m-SYT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Syt1 (synaptotagmin I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AW124717; G630098F17Rik; SytI

Description (Vector)

SYT1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Gene ID

20979

Gene Name (Vector)

synaptotagmin I

Gene Symbol

Syt1

ORF Size (aa)

1266

ORF Size (bp)

1266 bp

RefSeq ID

NM_009306

RefSeq Synonyms

NM_009306, NM_001252342, NM_001252341, BC042519,

Species

mouse

UniGene ID

Mm.289702

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.