mouse SF3B4 shRNA silencing AAV

Name
AAV-m-SF3B4-shRNA

Cat No
shAAV-271787

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Sf3b4.

shAAV-271787

AAV-m-SF3B4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Sf3b4 (splicing factor 3b, subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Sap49; SF3b49; SF3b50

Description (Vector)

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Gene ID

107701

Gene Name (Vector)

splicing factor 3b, subunit 4

Gene Symbol

Sf3b4

ORF Size (aa)

1275

ORF Size (bp)

1275 bp

RefSeq ID

NM_153053

RefSeq Synonyms

NM_153053, BC085273, BC026567, BC024418,

Species

mouse

UniGene ID

Mm.219671

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.