mouse RSPO1 shRNA silencing AAV

Name
AAV-m-RSPO1-shRNA

Cat No
shAAV-271184

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Rspo1.

shAAV-271184

AAV-m-RSPO1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Rspo1 (R-spondin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

R-spondin; Rspondin

Description (Vector)

Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Gene ID

192199

Gene Name (Vector)

R-spondin 1

Gene Symbol

Rspo1

ORF Size (aa)

798

ORF Size (bp)

798 bp

RefSeq ID

NM_138683

RefSeq Synonyms

NM_138683, BC138833, BC138831,

Species

mouse

UniGene ID

Mm.42202

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.