mouse RNF11 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rnf11.
shAAV-270666
AAV-m-RNF11-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rnf11 (ring finger protein 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Gene ID
29864
Gene Name (Vector)
ring finger protein 11
Gene Symbol
Rnf11
ORF Size (aa)
465
RefSeq ID
NM_013876
RefSeq Synonyms
NM_013876, BC028255, BC010299,
Species
mouse
UniGene ID
Mm.456388
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.