mouse RIPK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ripk3.
shAAV-270614
AAV-m-RIPK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ripk3 (receptor-interacting serine-threonine kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610528K09Rik; AW107945; Rip3
Description (Vector)
Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).
Gene ID
56532
Gene Name (Vector)
receptor-interacting serine-threonine kinase 3
Gene Symbol
Ripk3
ORF Size (aa)
1461
ORF Size (bp)
1461 bp
RefSeq ID
NM_019955
RefSeq Synonyms
NM_019955, NM_001164108, NM_001164107, BC029210,
Species
mouse
UniGene ID
Mm.46612
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.