mouse RBPJ shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rbpj.
shAAV-270295
AAV-m-RBPJ-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rbpj (recombination signal binding protein for immunoglobulin kappa J region). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBP-Jkappa; RBPjk; Rbpsuh
Description (Vector)
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.
Gene ID
19664
Gene Name (Vector)
recombination signal binding protein for immunoglobulin kappa J region
Gene Symbol
Rbpj
ORF Size (aa)
1464
ORF Size (bp)
1464 bp
RefSeq ID
NM_009035
RefSeq Synonyms
NM_009035, NM_001277116, NM_001080928, NM_001080927, BC051387,
Species
mouse
UniGene ID
Mm.209292
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.