mouse RASSF5 shRNA silencing AAV

Cat. No: shAAV-270201

Availability: 6-8 weeks

Name: AAV-m-RASSF5-shRNA

This is an AAV expressing shRNA for silencing of Mouse Rassf5.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rassf5
Gene Name: Ras association (RalGDS/AF-6) domain family member 5
Gene ID: 54354
Gene Synonyms: 1300019G20Rik; Maxp1; Nore1; Nore1A; Nore1B; Rapl
ORF Size: 1242 bp
RefSeq#: NM_018750
Gene Description: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.
UniGene ID: Mm.248291