mouse RARB shRNA silencing AAV

Name
AAV-m-RARB-shRNA

Cat No
shAAV-270149

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Rarb.

shAAV-270149

AAV-m-RARB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Rarb (retinoic acid receptor, beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A830025K23; Hap; Nr1b2

Description (Vector)

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

Gene ID

218772

Gene Name (Vector)

retinoic acid receptor, beta

Gene Symbol

Rarb

ORF Size (aa)

1347

ORF Size (bp)

1347 bp

RefSeq ID

NM_011243

RefSeq Synonyms

NM_011243, NM_001289762, NM_001289761, NM_001289760, BC076597,

Species

mouse

UniGene ID

Mm.259318

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.