mouse PTPRB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ptprb.
shAAV-269812
AAV-m-PTPRB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ptprb (protein tyrosine phosphatase, receptor type, B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3230402H02Rik; C130094E24; Ptpz; Rptpb; VE-PTP; Veptp
Description (Vector)
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Gene ID
19263
Gene Name (Vector)
protein tyrosine phosphatase, receptor type, B
Gene Symbol
Ptprb
ORF Size (aa)
5997
ORF Size (bp)
5997 bp
RefSeq ID
NM_029928
RefSeq Synonyms
NM_029928, BC145111, BC141006,
Species
mouse
UniGene ID
Mm.37213
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.