mouse PMAIP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Pmaip1.
shAAV-268926
AAV-m-PMAIP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Noxa
Description (Vector)
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Gene ID
58801
Gene Name (Vector)
phorbol-12-myristate-13-acetate-induced protein 1
Gene Symbol
Pmaip1
ORF Size (aa)
312
RefSeq ID
NM_021451
RefSeq Synonyms
NM_021451, BC050821,
Species
mouse
UniGene ID
Mm.271878
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.