mouse PIAS3 shRNA silencing AAV

Name
AAV-m-PIAS3-shRNA

Cat No
shAAV-268598

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Pias3.

shAAV-268598

AAV-m-PIAS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Pias3 (protein inhibitor of activated STAT 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Pias3l

Description (Vector)

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.

Gene ID

229615

Gene Name (Vector)

protein inhibitor of activated STAT 3

Gene Symbol

Pias3

ORF Size (aa)

1887

ORF Size (bp)

1887 bp

RefSeq ID

NM_018812

RefSeq Synonyms

NM_146135, NM_018812, NM_001165949, BC051252, BC023128,

Species

mouse

UniGene ID

Mm.1635

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.