mouse PFTK1 shRNA silencing AAV

Cat. No: shAAV-268456

Availability: 4-5 weeks

Name: AAV-m-PFTK1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Cdk14.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Cdk14
Gene Name: cyclin-dependent kinase 14
Gene ID: 18647
Gene Synonyms: mKIAA0834; Pftk1
ORF Size: 1272 bp
RefSeq#: NM_011074
Gene Description: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
UniGene ID: Mm.404502