mouse PARN shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Parn.
shAAV-268073
AAV-m-PARN-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Parn (poly(A)-specific ribonuclease (deadenylation nuclease)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1200003I18Rik; DAN
Description (Vector)
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
Gene ID
74108
Gene Name (Vector)
poly(A)-specific ribonuclease (deadenylation nuclease)
Gene Symbol
Parn
ORF Size (aa)
1875
ORF Size (bp)
1875 bp
RefSeq ID
NM_028761
RefSeq Synonyms
NM_028761, BC021899,
Species
mouse
UniGene ID
Mm.182350
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.