mouse NSMCE1 shRNA silencing AAV

Cat. No: shAAV-266114

Availability: 4-5 weeks

Name: AAV-m-NSMCE1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Nsmce1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Nsmce1
Gene Name: NSE1 homolog, SMC5-SMC6 complex component
Gene ID: 67711
Gene Synonyms: 2510027N19Rik
ORF Size: 843 bp
RefSeq#: NM_026330
Gene Description: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.
UniGene ID: Mm.4467