mouse NRP1 shRNA silencing AAV

Name
AAV-m-NRP1-shRNA

Cat No
shAAV-266094

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Nrp1.

shAAV-266094

AAV-m-NRP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nrp1 (neuropilin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C530029I03; NP-1; NPN-1; Npn1; Nrp

Description (Vector)

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis|Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene ID

18186

Gene Name (Vector)

neuropilin 1

Gene Symbol

Nrp1

ORF Size (aa)

2772

ORF Size (bp)

2772 bp

RefSeq ID

NM_008737

RefSeq Synonyms

NM_008737, BC060129,

Species

mouse

UniGene ID

Mm.423531

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.