mouse NR1H3 shRNA silencing AAV

Name
AAV-m-NR1H3-shRNA

Cat No
shAAV-266035

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nr1h3.

shAAV-266035

AAV-m-NR1H3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nr1h3 (nuclear receptor subfamily 1, group H, member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AU018371; LXR; RLD1; Unr1

Description (Vector)

Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

Gene ID

22259

Gene Name (Vector)

nuclear receptor subfamily 1, group H, member 3

Gene Symbol

Nr1h3

ORF Size (aa)

1338

ORF Size (bp)

1338 bp

RefSeq ID

NM_013839

RefSeq Synonyms

NM_013839, NM_001177730, BC012646,

Species

mouse

UniGene ID

Mm.22690

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.