mouse NOD1 shRNA silencing AAV

Name
AAV-m-NOD1-shRNA

Cat No
shAAV-265907

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nod1.

shAAV-265907

AAV-m-NOD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nod1 (nucleotide-binding oligomerization domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C230079P11; Card4; F830007N14Rik; Nlrc1

Description (Vector)

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.

Gene ID

107607

Gene Name (Vector)

nucleotide-binding oligomerization domain containing 1

Gene Symbol

Nod1

ORF Size (aa)

2862

ORF Size (bp)

2862 bp

RefSeq ID

NM_172729

RefSeq Synonyms

NM_172729, NM_001171007, BC042670,

Species

mouse

UniGene ID

Mm.28498

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.