mouse NFKBIZ shRNA silencing AAV

Name
AAV-m-NFKBIZ-shRNA

Cat No
shAAV-265731

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Nfkbiz.

shAAV-265731

AAV-m-NFKBIZ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AA408868; INAP; Mail

Description (Vector)

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).

Gene ID

80859

Gene Name (Vector)

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

Gene Symbol

Nfkbiz

ORF Size (aa)

2187

ORF Size (bp)

2187 bp

RefSeq ID

NM_030612

RefSeq Synonyms

NM_030612, NM_001159395, NM_001159394, BC058188,

Species

mouse

UniGene ID

Mm.247272

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.