mouse NF2 shRNA silencing AAV

Name
AAV-m-NF2-shRNA

Cat No
shAAV-265700

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Nf2.

shAAV-265700

AAV-m-NF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nf2 (neurofibromin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

merlin

Description (Vector)

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Gene ID

18016

Gene Name (Vector)

neurofibromin 2

Gene Symbol

Nf2

ORF Size (aa)

1062

ORF Size (bp)

1062 bp

RefSeq ID

NM_010898

RefSeq Synonyms

NM_010898, NM_001252253, NM_001252252, NM_001252251, NM_001252250, BC005442,

Species

mouse

UniGene ID

Mm.297109

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.