mouse NDP shRNA silencing AAV

Name
AAV-m-NDP-shRNA

Cat No
shAAV-265545

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Ndp.

shAAV-265545

AAV-m-NDP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ndp (Norrie disease (pseudoglioma) (human)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ND; Ndph

Description (Vector)

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Gene ID

17986

Gene Name (Vector)

Norrie disease (pseudoglioma) (human)

Gene Symbol

Ndp

ORF Size (aa)

396

ORF Size (bp)

396 bp

RefSeq ID

NM_010883

RefSeq Synonyms

NM_010883, BC090623,

Species

mouse

UniGene ID

Mm.5014

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.