mouse MTM1 shRNA silencing AAV

Name 
AAV-m-MTM1-shRNA
Cat No 
shAAV-265145
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Mtm1.

shAAV-265145
AAV-m-MTM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mtm1 (X-linked myotubular myopathy gene 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AF073996; mKIAA4176; Mtm
Description (Vector)
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
Gene ID
17772
Gene Name (Vector)
X-linked myotubular myopathy gene 1
Gene Symbol
Mtm1
ORF Size (aa)
1812
ORF Size (bp)
1812 bp
RefSeq ID
NM_019926
RefSeq Synonyms
NM_019926, NM_001164193, NM_001164192, NM_001164191, NM_001164190, BC090984,
Species
mouse
UniGene ID
Mm.423278

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.